MIF mediates bladder pain, not inflammation, in cyclophosphamide cystitis
نویسندگان
چکیده
منابع مشابه
Bladder Pain Syndrome/Interstitial cystitis:
Background BPS/IC is a chronic syndrome with bladder pain, divided into two main types: one with so called Hunner`s lesions (classic type) and one without (nonulcer type). In the recently presented ESSIC classification system the classic type, in focus of the present work, has the designation Type 3C BPS/IC. Symptoms are characterized by bladder pain, urgency, frequency and nocturia. The aetiol...
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212 CYCLOPHOSPHAMIDE-INDUCED CHRONIC CYSTITIS ENHANCES PAIN BEHAVIOR AND BLADDER CAPACITY REDUCTION ELICITED BY RESINIFERATOXIN IN RATS Tomohiko Oguchi, Osamu Nishizawa, Naoki Yoshimura The authors note that while rats with chronic cystitis induced by repeated cyclophosphamide (CYP) injections have been used for basic research of hypersensitive bladder disorders including BPS/IC, changes in pai...
متن کاملProtease-Activated Receptor 4 Induces Bladder Pain through High Mobility Group Box-1
Pain is the significant presenting symptom in Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS). Activation of urothelial protease activated receptor 4 (PAR4) causes pain through release of urothelial macrophage migration inhibitory factor (MIF). High Mobility Group Box-1 (HMGB1), a chromatin-binding protein, mediates bladder pain (but not inflammation) in an experimental model (cyclophos...
متن کاملMast Cell-Derived Histamine Mediates Cystitis Pain
BACKGROUND Mast cells trigger inflammation that is associated with local pain, but the mechanisms mediating pain are unclear. Interstitial cystitis (IC) is a bladder disease that causes debilitating pelvic pain of unknown origin and without consistent inflammation, but IC symptoms correlate with elevated bladder lamina propria mast cell counts. We hypothesized that mast cells mediate pelvic pai...
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ژورنال
عنوان ژورنال: Cytokine: X
سال: 2019
ISSN: 2590-1532
DOI: 10.1016/j.cytox.2019.100003